Article
Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis.
The European respiratory journal - 1 Sept 1997
Ho L P, Samways J M, Porteous D J, Dorin J R, Carothers A, Greening A P, Innes J A
Abstract excerpt
In cystic fibrosis (CF), the clinical condition of patients correlates poorly with genotype. One possible explanation is that clinical status is influenced by net preserved chloride secretion rather than the CF mutation. We tested the relationships between residual chloride secretion, as measured by nasal potential difference (PD) and the type of mutation (genotypes expressing apical cystic fibrosis transmembrane...
Topics
- Adult
- Amiloride
- Chlorides
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Female
- Forced Expiratory Volume
- Genotype
- Humans
- Isoproterenol
- Male
- Membrane Potentials
- Mutation
- Nasal Mucosa