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Article

Insights into the variability of nasal potential difference, a biomarker of CFTR activity.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2020

Kyrilli Spyridoula, Henry Theophraste, Wilschanski Michael, Fajac Isabelle, Davies Jane C, Jais Jean-Philippe, Sermet-Gaudelus Isabelle

Abstract excerpt

BACKGROUND: Nasal potential difference (NPD) is used to evaluate CFTR function in vivo. We aimed to evaluate the intrasubject and intersubject variability of NPD measurements. METHODS: We reviewed NPD tracings of 116 patients with CF enrolled in the placebo arm of a multicenter study. Patients carried at least one nonsense mutation and underwent repeated NPD tests every 16 weeks. NPD parameters included basal...

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Identifiers

PMID: 31699569
DOI: 10.1016/j.jcf.2019.09.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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