Article
Nasal potential difference in cystic fibrosis considering severe CFTR mutations.
Disease markers - 1 Jan 2015
Ng Ronny Tah Yen, Marson Fernando Augusto de Lima, Ribeiro Jose Dirceu, Ribeiro Antonio Fernando, Bertuzzo Carmen Silvia, Ribeiro Maria Angela Gonçalves de Oliveira, Severino Silvana Dalge, Sakano Eulalia
Abstract excerpt
The gold standard for diagnosing cystic fibrosis (CF) is a sweat chloride value above 60 mEq/L. However, this historical and important tool has limitations; other techniques should be studied, including the nasal potential difference (NPD) test. CFTR gene sequencing can identify CFTR mutations, but this method is time-consuming and too expensive to be used in all CF centers. The present study compared CF patients...
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