Article
Chloride Conductance, Nasal Potential Difference and Cystic Fibrosis Pathophysiology.
Lung - 1 Feb 2020
Procianoy Elenara da Fonseca Andrade, de Abreu E Silva Fernando Antônio, Maróstica Paulo José Cauduro, Quinton Paul M
Abstract excerpt
PURPOSE: Cystic fibrosis (CF) is a multisystem genetic disease caused by dysfunction of the epithelial anionic channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Decreased mucociliary clearance because of thickened mucus is part of the pulmonary disease pathophysiology. It is controversial if the thickened airway surface liquid (ASL) is caused by the deficient chloride secretion and excessive...
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