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Article

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

Science translational medicine - 8 Oct 2014

Tang Yunzhao, Axelsson Annika S, Spégel Peter, Andersson Lotta E, Mulder Hindrik, Groop Leif C, Renström Erik, Rosengren Anders H

Abstract excerpt

The feasibility of exploiting genomic information for individualized treatment of polygenic diseases remains uncertain. A genetic variant in ADRA2A, which encodes the α(2A)-adrenergic receptor (α(2A)AR), was recently associated with type 2 diabetes. This variant causes receptor overexpression and impaired insulin secretion; thus, we hypothesized that blocking α(2A)AR pharmacologically could improve insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Adrenergic, alpha-2

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Source

Identifiers

PMID: 25298321
DOI: 10.1126/scitranslmed.3009934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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