Article
Genetic association of adrenergic receptor alpha 2A with obesity and type 2 diabetes.
Obesity (Silver Spring, Md.) - 1 Aug 2013
Långberg Ewa-Carin, Seed Ahmed Mohammed, Efendic Suad, Gu Harvest F, Östenson Claes-Göran
Abstract excerpt
OBJECTIVE: The sympathetic nervous system (SNS) is linked to glucose, lipid, and protein metabolism. The α2A -adrenergic receptor (ADRA2A) is involved in the SNS and mediates inhibition of insulin secretion and lipolysis. The association of ADRA2A single-nucleotide polymorphisms (SNPs) with obesity and/or type 2 diabetes (T2D) was investigated. DESIGN AND METHODS: Genotyping was performed in a case-control study...
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