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Article

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.

Science (New York, N.Y.) - 8 Jan 2010

Rosengren Anders H, Jokubka Ramunas, Tojjar Damon, Granhall Charlotte, Hansson Ola, Li Dai-Qing, Nagaraj Vini, Reinbothe Thomas M, Tuncel Jonatan, Eliasson Lena, Groop Leif, Rorsman Patrik, Salehi Albert, Lyssenko Valeriya, Luthman Holger, Renström Erik

Abstract excerpt

Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to impaired insulin granule docking at...

Read the complete abstract on PubMed

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Share to Adrenergic alpha-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19965390
DOI: 10.1126/science.1176827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19965390-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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