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Article

The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1

9 Oct 2014

Abstract excerpt

CCCTC-binding factor (CTCF) is the major protein involved in insulator activity in vertebrates, with widespread DNA binding sites in the genome. CTCF participates in many processes related to global chromatin organization and remodeling, contributing to the repression or activation of gene transcription. It is also involved in epigenetic reprogramming and is essential during gametogenesis and embryo development....

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PMID: 25297545
DOI: 10.1095/biolreprod.114.122945

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The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1PMID 25297545Read ↗

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Genomic Imprinting: CTCF Protects the BoundariesSemantic proximity Read ↗

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Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator functionSemantic proximity Read ↗

The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster.Semantic proximity Read ↗

Epigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis.Semantic proximity Read ↗

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Cohesin mediates transcriptional insulation by CCCTC-binding factor.Semantic proximity Read ↗

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusSemantic proximity Read ↗

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