Article
Cohesin mediates transcriptional insulation by CCCTC-binding factor.
Nature - 14 Feb 2008
Wendt Kerstin S, Yoshida Keisuke, Itoh Takehiko, Bando Masashige, Koch Birgit, Schirghuber Erika, Tsutsumi Shuichi, Nagae Genta, Ishihara Ko, Mishiro Tsuyoshi, Yahata Kazuhide, Imamoto Fumio, Aburatani Hiroyuki, Nakao Mitsuyoshi, Imamoto Naoko, Maeshima Kazuhiro, Shirahige Katsuhiko, Peters Jan-Michael
Abstract excerpt
Cohesin complexes mediate sister-chromatid cohesion in dividing cells but may also contribute to gene regulation in postmitotic cells. How cohesin regulates gene expression is not known. Here we describe cohesin-binding sites in the human genome and show that most of these are associated with the CCCTC-binding factor (CTCF), a zinc-finger protein required for transcriptional insulation. CTCF is dispensable for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.