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Article

Transgenic RNAi Reveals Essential Function for CTCF in <i>H19</i> Gene Imprinting

9 Jan 2004

Abstract excerpt

The imprinted regulation of H19 and Insulin-like growth factor 2 expression involves binding of the vertebrate insulator protein, CCCTC binding factor (CTCF), to the maternally hypomethylated differentially methylated domain (DMD). How this hypomethylated state is maintained during oogenesis and the role of CTCF, if any, in this process are not understood. With the use of a transgenic RNA interference...

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PMID: 14716017
DOI: 10.1126/science.1090934

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Transgenic RNAi Reveals Essential Function for CTCF in <i>H19</i> Gene ImprintingPMID 14716017Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic MiceSemantic proximity Read ↗

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.Semantic proximity Read ↗

CTCF elements direct allele-specific undermethylation at the imprinted H19 locus.Semantic proximity Read ↗

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusSemantic proximity Read ↗

CTCF maintains differential methylation at the Igf2/H19 locus.Semantic proximity Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1Semantic proximity Read ↗

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceSemantic proximity Read ↗

Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo developmentSemantic proximity Read ↗

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainSemantic proximity Read ↗

<i>H19</i> Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ LineSemantic proximity Read ↗

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