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Article

CTCF elements direct allele-specific undermethylation at the imprinted H19 locus.

Current biology : CB - 8 Jun 2004

Rand Eyal, Ben-Porath Ittai, Keshet Ilana, Cedar Howard

Abstract excerpt

The H19 imprinted gene locus is regulated by an upstream 2 kb imprinting control region (ICR) that influences allele-specific expression, DNA methylation, and replication timing. This ICR becomes de novo methylated during late spermatogenesis in the male but emerges from oogenesis in an unmethylated form, and this allele-specific pattern is then maintained throughout early development and in all tissues of the...

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Source

Identifiers

PMID: 15182675
DOI: 10.1016/j.cub.2004.05.041

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CTCF elements direct allele-specific undermethylation at the imprinted H19 locus.PMID 15182675Read ↗

CTCF maintains differential methylation at the Igf2/H19 locus.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Oct4/Sox2 binding sites contribute to maintaining hypomethylation of the maternal igf2/h19 imprinting control region.Semantic proximity Read ↗

The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1Semantic proximity Read ↗

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceSemantic proximity Read ↗

The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic MiceSemantic proximity Read ↗

Transgenic RNAi Reveals Essential Function for CTCF in <i>H19</i> Gene ImprintingSemantic proximity Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

Fate of methylated/unmethylated H19 imprinting control region after paternal and maternal pronuclear injection.Semantic proximity Read ↗

Genomic Imprinting: CTCF Protects the BoundariesSemantic proximity Read ↗

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainSemantic proximity Read ↗

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusSemantic proximity Read ↗

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