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Article

Characterization of susceptibility variants of influenza virus grown in the presence of T-705.

Journal of pharmacological sciences - 1 Jan 2014

Daikoku Tohru, Yoshida Yoshihiro, Okuda Tomoko, Shiraki Kimiyasu

Abstract excerpt

T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strain had amino acid variations in the PB1, PB2, and PA genes of the RNA polymerase complex. However, the variation patterns in the...

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Identifiers

PMID: 25296868
DOI: 10.1254/jphs.14156sc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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