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Attenuated Strains of Influenza A Viruses Do Not Induce Degradation of RNA Polymerase II

20 Aug 2009

Abstract excerpt

We have previously shown that infection with laboratory-passaged strains of influenza virus causes both specific degradation of the largest subunit of the RNA polymerase II complex (RNAP II) and inhibition of host cell transcription. When infection with natural human and avian isolates belonging to different antigenic subtypes was examined, we observed that all of these viruses efficiently induce the proteolytic...

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PMID: 19692472
DOI: 10.1128/jvi.01439-09

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