Article
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase.
Journal of virology - 15 Jun 2017
Abdelnabi Rana, Morais Ana Theresa Silveira de, Leyssen Pieter, Imbert Isabelle, Beaucourt Stéphanie, Blanc Hervé, Froeyen Mathy, Vignuzzi Marco, Canard Bruno, Neyts Johan, Delang Leen
Abstract excerpt
Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV). We demonstrated earlier that the K291R mutation in the F1 motif of the RNA-dependent RNA polymerase (RdRp) of CHIKV is responsible for low-level resistance to T-705. Interestingly,...
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