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Article

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

The Journal of antimicrobial chemotherapy - 1 Oct 2014

Delang Leen, Segura Guerrero Nidya, Tas Ali, Quérat Gilles, Pastorino Boris, Froeyen Mathy, Dallmeier Kai, Jochmans Dirk, Herdewijn Piet, Bello Felio, Snijder Eric J, de Lamballerie Xavier, Martina Byron, Neyts Johan, van Hemert Martijn J, Leyssen Pieter

Abstract excerpt

OBJECTIVES: T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This molecule also inhibits the replication of a broad spectrum of other RNA viruses. The objective of this study was to investigate the antiviral effect of favipiravir on chikungunya virus (CHIKV) replication and to contribute to unravelling the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24951535
DOI: 10.1093/jac/dku209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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