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Article

PA subunit of RNA polymerase as a promising target for anti-influenza virus agents.

Antiviral research - 1 Jun 2008

Nakazawa Misako, Kadowaki Shin-etsu, Watanabe Izumi, Kadowaki Youko, Takei Masaya, Fukuda Hideyuki

Abstract excerpt

RNA polymerase of influenza virus is a specific enzyme necessary for the viral replication. A siRNA against the RNA polymerase and the RNA polymerase inhibitor L-742,001 reduced accumulation of viral RNAs in the infected cells. L-742,001 strongly inhibited virus re-growth after removal of the agent from the culture, whereas the neuraminidase inhibitor zanamivir did not. L-742,001-resistant mutants showed a Thr-20...

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Identifiers

PMID: 18258312
DOI: 10.1016/j.antiviral.2007.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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