Article
Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.
Antimicrobial agents and chemotherapy - 1 Nov 2016
Vanderlinden Evelien, Vrancken Bram, Van Houdt Jeroen, Rajwanshi Vivek K, Gillemot Sarah, Andrei Graciela, Lemey Philippe, Naesens Lieve
Abstract excerpt
T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy. It is supposed to act as an alternative substrate for the viral polymerase, causing inhibition of viral RNA synthesis or virus mutagenesis. These mechanisms were also proposed for ribavirin, an established and broad antiviral drug that shares structural similarity with T-705. We here performed a comparative...
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