Article
Gastrointestinal stromal tumors: who should get imatinib and for how long?
Advances in surgery - 1 Jan 2014
Balachandran Vinod P, DeMatteo Ronald P
Abstract excerpt
The application of imatinib for the treatment of GIST remains a remarkable illustration of the ability and promise of targeted molecular therapy. It is gradually becoming evident that the benefit of imatinib depends on the complex interplay between mutational variations that govern tumor sensitivity to the drug, and biological variables that drive clinical outcome. Evidence is mounting that only a select fraction...
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