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Article

Beyond the Driver Mutation: Immunotherapies in Gastrointestinal Stromal Tumors.

Frontiers in immunology - 1 Jan 2021

Roulleaux Dugage Matthieu, Jones Robin Lewis, Trent Jonathan, Champiat Stéphane, Dumont Sarah

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are a subtype of soft tissue sarcoma (STS), and have become a concept of oncogenic addiction and targeted therapies.The large majority of these tumors develop after a mutation in KIT or platelet derived growth factor receptor α (PDGFRα), resulting in uncontrolled proliferation. GISTs are highly sensitive to imatinib. GISTs are immune infiltrated tumors with a predominance...

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Identifiers

PMID: 34489967
DOI: 10.3389/fimmu.2021.715727
PMCID: PMC8417712

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