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Article

Gastrointestinal Stromal Tumors: What Is the Best Sequence of TKIs?

Current treatment options in oncology - 1 May 2022

Senchak Jordan, Ahr Katya, von Mehren Margaret

Abstract excerpt

OPINION STATEMENT: In our practice, we evaluate the mutation status of advanced unresectable disease to guide decisions on use of tyrosine kinase inhibitor (TKI) therapy. This review focuses on management of GIST with KIT and PDGFRA mutations. Imatinib is first-line treatment for unresectable gastrointestinal stromal tumors (GISTs) unless they harbor a PDGFRA D842V mutation; it is recommended to escalate imatinib...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35349049
DOI: 10.1007/s11864-022-00958-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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