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Article

Imatinib treatment for gastrointestinal stromal tumour (GIST).

Journal of cellular and molecular medicine - 1 Jan 2010

Lopes Lisandro F, Bacchi Carlos E

Abstract excerpt

Gastrointestinal stromal tumour (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. GISTs are believed to originate from intersticial cells of Cajal (the pacemaker cells of the gastrointestinal tract) or related stem cells, and are characterized by KIT or platelet-derived growth factor receptor alpha (PDGFRA) activating mutations. The use of imatinib has revolutionized the management of...

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Source

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Identifiers

PMID: 19968734
DOI: 10.1111/j.1582-4934.2009.00983.x
PMCID: PMC3837608

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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