Article
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
Nature - 10 Nov 2016
Dong Lei, Yu Wen-Mei, Zheng Hong, Loh Mignon L, Bunting Silvia T, Pauly Melinda, Huang Gang, Zhou Muxiang, Broxmeyer Hal E, Scadden David T, Qu Cheng-Kui
Abstract excerpt
Germline activating mutations of the protein tyrosine phosphatase SHP2 (encoded by PTPN11), a positive regulator of the RAS signalling pathway, are found in 50% of patients with Noonan syndrome. These patients have an increased risk of developing leukaemia, especially juvenile myelomonocytic leukaemia (JMML), a childhood myeloproliferative neoplasm (MPN). Previous studies have demonstrated that mutations in...
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