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Article

HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.

Physiological genomics - 24 Jun 2003

Treinin Millet, Shliar Judith, Jiang Huaqi, Powell-Coffman Jo Anne, Bromberg Zohar, Horowitz Michal

Abstract excerpt

Chronic exposure to environmental heat improves tolerance via heat acclimation (AC). Our previous data on mammals indicate that reprogramming the expression of genes coding for stress proteins and energy-metabolism enzymes plays a major role. Knowledge of pathways leading to AC is limited. For their identification, we established a Caenorhabditis elegans AC model and tested mutants in which signaling pathways...

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Identifiers

PMID: 12686697
DOI: 10.1152/physiolgenomics.00179.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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