Article
Role of Erbin in ErbB2-dependent breast tumor growth.
Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014
Tao Yanmei, Shen Chengyong, Luo Shiwen, Traoré Wilfried, Marchetto Sylvie, Santoni Marie-Josée, Xu Linlin, Wu Biao, Shi Chao, Mei Jinghong, Bates Ryan, Liu Xihui, Zhao Kai, Xiong Wen-Cheng, Borg Jean-Paul, Mei Lin
Abstract excerpt
ErbB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), a receptor tyrosine kinase of the ErbB family, is overexpressed in around 25% of breast cancers. In addition to forming a heterodimer with other ErbB receptors in response to ligand stimulation, ErbB2 can be activated in a ligand-independent manner. We report here that Erbin, an ErbB2-interacting protein that was thought to act as an...
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