Article
The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology.
The International journal of developmental biology - 1 Jan 2011
Eccles Suzanne A
Abstract excerpt
The EGFR/Erb-B receptor tyrosine kinases each play distinct and complementary roles in normal breast development. The four receptors form both homodimers and heterodimers in response to binding by ligands which show selectivity for one or more of the receptors (except Erb-B2). Together with the additional flexibility generated by the formation of different dimer pairs, these signalling networks play key roles in...
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