Article
ErbB receptors: directing key signaling networks throughout life.
Annual review of pharmacology and toxicology - 1 Jan 2004
Holbro Thomas, Hynes Nancy E
Abstract excerpt
The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the formation of different homo- and heterodimers. Receptor dimerization promotes activation of the intrinsic kinase, leading to phosphorylation of specific tyrosines located in the ErbB's cytoplasmic region. These phosphorylated residues serve as docking sites for a variety of signaling molecules whose recruitment stimulates...
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