Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ErbB receptors and signaling pathways in cancer.

Current opinion in cell biology - 1 Apr 2009

Hynes Nancy E, MacDonald Gwen

Abstract excerpt

The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer. Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many epithelial tumors, and clinical studies suggest that they play roles in cancer development and progression. These receptors have been intensely studied, not only to understand the mechanisms underlying their oncogenic potential, but also to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, ErbB-2

Share to Trastuzumab

Source

Identifiers

PMID: 19208461
DOI: 10.1016/j.ceb.2008.12.010

Genes

EGFR
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ErbB receptors and signaling pathways in cancer.PMID 19208461Read ↗

ErbB Receptors and Cancer.Semantic proximity Read ↗

Targeting ErbB receptor signaling: A pan-ErbB approach to cancerSemantic proximity Read ↗

HER2/PI3K/AKT pathway in HER2-positive breast cancer: A reviewSemantic proximity Read ↗

Intracellular signaling pathways of ErbB2/HER-2 and family membersSemantic proximity Read ↗

The Biological Roles and Clinical Applications of the PI3K/AKT Pathway in Targeted Therapy Resistance in HER2-Positive Breast Cancer: A Comprehensive ReviewSemantic proximity Read ↗

ErbB receptors: from oncogenes to targeted cancer therapiesSemantic proximity Read ↗

ErbB receptors: directing key signaling networks throughout life.Semantic proximity Read ↗

EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review)Semantic proximity Read ↗

The ErbB/HER receptor protein-tyrosine kinases and cancer.Semantic proximity Read ↗

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challengesSemantic proximity Read ↗

Genomic alterations of ERBB receptors in cancer: clinical implicationsSemantic proximity Read ↗

ErbB/HER family in cancer immunology: therapeutic advances and mechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.