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ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy

7 Oct 2016

Abstract excerpt

Approximately 15-20% of breast cancers (BC) show either membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 gene amplification. Until the development of MErbB-2-targeted therapies, this BC subtype, called ErbB-2-positive, was associated with increased metastatic potential and poor prognosis. Although these therapies have significantly improved overall...

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PMID: 27765799
DOI: 10.1530/erc-16-0360

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