Article
Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.
PloS one - 1 Jan 2013
Mishra Nagendra N, Yang Soo-Jin, Chen Liang, Muller Claudette, Saleh-Mghir Azzam, Kuhn Sebastian, Peschel Andreas, Yeaman Michael R, Nast Cynthia C, Kreiswirth Barry N, Crémieux Anne-Claude, Bayer Arnold S
Abstract excerpt
BACKGROUND: Previous studies of both clinically-derived and in vitro passage-derived daptomycin-resistant (DAP-R) Staphylococcus aureus strains demonstrated the coincident emergence of increased DAP MICs and resistance to host defense cationic peptides (HDP-R). METHODS: In the present investigation, we studied a parental DAP-susceptible (DAP-S) methicillin-resistant Staphylococcus aureus (MRSA) strain and three...
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