Article
The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata.
Antimicrobial agents and chemotherapy - 1 Sept 2012
Shields Ryan K, Nguyen M Hong, Press Ellen G, Kwa Andrea L, Cheng Shaoji, Du Chen, Clancy Cornelius J
Abstract excerpt
Echinocandins are frontline agents against invasive candidiasis (IC), but predictors for echinocandin therapeutic failure have not been well defined. Mutations in Candida FKS genes, which encode the enzyme targeted by echinocandins, result in elevated MICs and have been linked to therapeutic failures. In this study, echinocandin MICs by broth microdilution and FKS1 and FKS2 mutations among C. glabrata isolates...
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