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Article

Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2013

Alexander Barbara D, Johnson Melissa D, Pfeiffer Christopher D, Jiménez-Ortigosa Cristina, Catania Jelena, Booker Rachel, Castanheira Mariana, Messer Shawn A, Perlin David S, Pfaller Michael A

Abstract excerpt

BACKGROUND: Fluconazole (FLC) resistance is common in C. glabrata and echinocandins are often used as first-line therapy. Resistance to echinocandin therapy has been associated with FKS1 and FKS2 gene alterations. METHODS: We reviewed records of all patients with C. glabrata bloodstream infection at Duke Hospital over the past decade (2001-2010) and correlated treatment outcome with minimum inhibitory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23487382
DOI: 10.1093/cid/cit136
PMCID: PMC3658363

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