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Article

ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53

6 Oct 2014

Abstract excerpt

Abraxas brother 1 (ABRO1) has been reported to be a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. However, current knowledge of the functions of ABRO1 is limited. Here we report that ABRO1 is frequently downregulated in human liver, kidney, breast and thyroid gland tumour tissues. Depletion of ABRO1 in cancer cells reduces p53 levels and enhances clone...

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PMID: 25283148
DOI: 10.1038/ncomms6059

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