Article
The association between APOL1 risk alleles and longitudinal kidney function differs by HIV viral suppression status.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Feb 2015
Estrella Michelle M, Li Man, Tin Adrienne, Abraham Alison G, Shlipak Michael G, Penugonda Sudhir, Hussain Shehnaz K, Palella Frank J, Wolinsky Steven M, Martinson Jeremy J, Parekh Rulan S, Kao W H Linda
Abstract excerpt
BACKGROUND: Existing data suggest that human immunodeficiency virus (HIV)-infected African Americans carrying 2 copies of the APOL1 risk alleles have greater risk of kidney disease than noncarriers. We sought to determine whether HIV RNA suppression mitigates APOL1-related kidney function decline among African Americans enrolled in the Multicenter AIDS Cohort Study. METHODS: We genotyped HIV-infected men for the...
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