Article
HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics.
Kidney international - 1 Aug 2012
Atta Mohamed G, Estrella Michelle M, Kuperman Michael, Foy Matthew C, Fine Derek M, Racusen Lorraine C, Lucas Gregory M, Nelson George W, Warner Andrew C, Winkler Cheryl A, Kopp Jeffrey B
Abstract excerpt
Recently, an association was found between nondiabetic kidney disease in African Americans and two independent sequence variants in the APOL1 gene, encoding apolipoprotein L1. In this study we determined the frequency of APOL1 risk variants in patients with biopsy-proven HIV-associated nephropathy (HIVAN) and distinctive pathological characteristics potentially driven by those risk variants. Among 76 patients...
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