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Article

Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit

10 Oct 2016

Abstract excerpt

Ribosomes of trypanosomatids, a family of protozoan parasites causing debilitating human diseases, possess multiply fragmented rRNAs that together are analogous to 28S rRNA, unusually large rRNA expansion segments, and r-protein variations compared with other eukaryotic ribosomes. To investigate the architecture of the trypanosomatid ribosomes, we determined the 2.5-Å structure of the Trypanosoma cruzi ribosome...

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PMID: 27791004
DOI: 10.1073/pnas.1614594113

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