Article
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
Genes and immunity - 1 Mar 2016
Berge T, Leikfoss I S, Brorson I S, Bos S D, Page C M, Gustavsen M W, Bjølgerud A, Holmøy T, Celius E G, Damoiseaux J, Smolders J, Harbo H F, Spurkland A
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals. The majority of the MS-associated gene variants are located in genetic regions with importance for T-cell differentiation. Vitamin D is a potent immunomodulator, and vitamin D deficiency has been suggested to be associated with increased MS disease susceptibility...
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