Article
Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions.
Oncotarget - 30 Oct 2014
Sakai Kazuko, Kazama Shinsuke, Nagai Yuzo, Murono Koji, Tanaka Toshiaki, Ishihara Soichiro, Sunami Eiji, Tomida Shuta, Nishio Kazuto, Watanabe Toshiaki
Abstract excerpt
Neoadjuvant chemoradiotherapy has been introduced in patients with surgically resected rectal cancer and reduced the local recurrence. Heterogeneity exists in rectal cancer, and we hypothesized that there are subclones resistant to chemoradiotherapy within the cancer mass. We performed DNA-targeted sequencing of pre- and post-treatment tumor tissues obtained from 20 rectal cancer patients who received...
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