Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor mutation burden in blood predicts benefit from neoadjuvant chemo/radiotherapy in locally advanced rectal cancer.

Genomics - 1 Jan 2021

Ji Dengbo, Zhang Dakui, Zhan Tiancheng, Jia Jinying, Han Wenbo, Li Zhaowei, Li Ming, Song Can, Wang Jianfei, Gu Jin

Abstract excerpt

Distant metastasis has been the major concern of prognosis in patients with locally advanced rectal cancer (LARC). The purpose of this study was to investigate the prognostic value of TMB in blood (bTMB) in LARC patients after receiving neoadjuvant chemoradiotherapy (nCRT) and surgery. Using targeted ctDNA sequencing, we revealed that bTMB level at baseline was positively correlated with recurrence-free survival...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Chemoradiotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circulating Tumor DNA

Share to Clonal Evolution

Share to Cytokines

Share to Neoadjuvant Therapy

Share to Rectal Neoplasms

Share to Survival Analysis

Source

Identifiers

PMID: 33129922
DOI: 10.1016/j.ygeno.2020.10.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor mutation burden in blood predicts benefit from neoadjuvant chemo/radiotherapy in locally advanced rectal cancer.PMID 33129922Read ↗

Serial Circulating Tumor DNA in Predicting and Monitoring the Effect of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer: A Prospective Multicenter Study.Semantic proximity Read ↗

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study.Semantic proximity Read ↗

Predictive and Prognostic Molecular Biomarkers for Response to Neoadjuvant Chemoradiation in Rectal Cancer.Semantic proximity Read ↗

Exploration of the role of tumor mutation burden in clinical significance, immunotherapy response predictor and immune cell infiltration in colon cancerSemantic proximity Read ↗

Exploring novel inflammation-related genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancerSemantic proximity Read ↗

Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases.Semantic proximity Read ↗

KRAS Mutant Status May Be Associated with Distant Recurrence in Early-stage Rectal Cancer.Semantic proximity Read ↗

An Integrated Model of Pathological Complete Response and Postoperative CEA Predicts Survival and Benefit of Adjuvant Chemotherapy for Locally Advanced Rectal CancerSemantic proximity Read ↗

Identification of neoadjuvant radiotherapy resistance genes in rectal cancer using integrated bioinformatics analysisSemantic proximity Read ↗

Neoadjuvant Chemotherapy plus Bevacizumab Combined with Total Mesorectal Excision in Treating Locally Advanced Rectal Cancer Patients with BRAF Mutation: Clinical Benefit and Safety.Semantic proximity Read ↗

A Genotype Signature for Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer.Semantic proximity Read ↗

A good preoperative immune prognostic index is predictive of better prognosis for locally advanced rectal cancer patients with ypTNM stage II who underwent radical resection after neoadjuvant chemoradiotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.