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Article

Bacteria-based analysis of HIV-1 Vpu channel activity.

PloS one - 1 Jan 2014

Taube Robert, Alhadeff Raphael, Assa Dror, Krugliak Miriam, Arkin Isaiah T

Abstract excerpt

HIV-1 Vpu is a small, single-span membrane protein with two attributed functions that increase the virus' pathogenicity: degradation of CD4 and inactivation of BST-2. Vpu has also been shown to possess ion channel activity, yet no correlation has been found between this attribute and Vpu's role in viral release. In order to gain further insight into the channel activity of Vpu we devised two bacteria-based assays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25272035
DOI: 10.1371/journal.pone.0105387
PMCID: PMC4182682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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