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Vpu Protein: The Viroporin Encoded by HIV-1

4 Aug 2015

Abstract excerpt

Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in...

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PMID: 26247957
DOI: 10.3390/v7082824

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