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Article

In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach.

Journal of virological methods - 1 Feb 2017

Rahimi Asa, Anmole Gursev, Soto-Nava Maribel, Escamilla-Gomez Tania, Markle Tristan, Jin Steven W, Lee Guinevere Q, Harrigan P Richard, Bangsberg David R, Martin Jeffrey, Avila-Rios Santiago, Reyes-Teran Gustavo, Brockman Mark A, Brumme Zabrina L

Abstract excerpt

The HIV-1 accessory protein Vpu exhibits high inter- and intra- subtype genetic diversity that may influence Vpu function and possibly contribute to HIV-1 pathogenesis. However, scalable methods to evaluate genotype/phenotype relationships in natural Vpu sequences are limited, particularly those expressing the protein in CD4+ T-cells, the natural target of HIV-1 infection. A major impediment to assay scalability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27865749
DOI: 10.1016/j.jviromet.2016.11.004
PMCID: PMC5183569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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