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Article

HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP.

Virology journal - 30 Sept 2014

Niederer Heather A, Laydon Daniel J, Melamed Anat, Elemans Marjet, Asquith Becca, Matsuoka Masao, Bangham Charles R M

Abstract excerpt

BACKGROUND: HTLV-1 causes proliferation of clonal populations of infected T cells in vivo, each clone defined by a unique proviral integration site in the host genome. The proviral load is strongly correlated with odds of the inflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is evidence that asymptomatic HTLV-1 carriers (ACs) have a more effective CD8 + T cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25270762
DOI: 10.1186/1743-422X-11-172
PMCID: PMC4192323

Genes

HBZ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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