Article
MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.
Mucosal immunology - 1 Mar 2015
Kurioka A, Ussher J E, Cosgrove C, Clough C, Fergusson J R, Smith K, Kang Y-H, Walker L J, Hansen T H, Willberg C B, Klenerman P
Abstract excerpt
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT cells are activated by a broad range of bacteria through detection of riboflavin metabolites bound by MR1, but their direct cytolytic capacity upon recognition of cognate target cells remains unclear. We show that resting human...
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