Article
MAIT cells altered phenotype and cytotoxicity in lupus patients are linked to renal disease severity and outcome.
Frontiers in immunology - 1 Jan 2023
Litvinova Elena, Bounaix Carine, Hanouna Guillaume, Da Silva Jennifer, Noailles Laura, Beaudoin Lucie, Padden Michael, Bellamri Nessrine, Lehuen Agnès, Daugas Eric, Monteiro Renato C, Flament Héloïse
Abstract excerpt
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease in which circulating immune complexes can cause different types of glomerulonephritis, according to immune deposits and to the type of glomerular cell injury. Proliferative lesions represent the most severe form of lupus nephritis (LN) and often lead to kidney failure and death. Mucosal-associated invariant T (MAIT) cells are a subset of...
Topics
- Humans
- Lupus Nephritis
- Mucosal-Associated Invariant T Cells
- Granzymes
- Lupus Erythematosus, Systemic
- Phenotype
- Patient Acuity