Article
Two polymorphisms of CD44 3'UTR weaken the binding of miRNAs and associate with naso-pharyngeal carcinoma in a Chinese population.
European review for medical and pharmacological sciences - 1 Jan 2014
Lou F, Ma H-N, Xu L, Chen M, Zhu Y-B
Abstract excerpt
OBJECTIVE: CD44 is a member of adhesion molecule families whose function is closely associated with cancer cell metastatic spread and drug resistance. CD44 is expressed as a wide variety of isoforms but 3' untranslated region (3'UTR) is conserved relatively and it is confirmed that more than ten miRNAs regulate the expression of CD44. The aim of this paper is to investigate the association between polymorphisms...
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