Article
Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Nov 2019
Tweats David, Eastmond David A, Lynch Anthony M, Elhajouji Azeddine, Froetschl Roland, Kirsch-Volders Micheline, Marchetti Francesco, Masumura Kenichi, Pacchierotti Francesca, Schuler Maik
Abstract excerpt
Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis....
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