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Article

Mutations in tyrosine kinase and tyrosine phosphatase and their relevance to the target therapy in hematologic malignancies.

Future oncology (London, England) - 1 Jan 2015

Zhu Ni, Xiao Haowen, Wang Li-Mengmeng, Fu Shan, Zhao Chan, Huang He

Abstract excerpt

Protein tyrosine kinases and protein tyrosine phosphatases play pivotal roles in regulation of cellular phosphorylation and signal transduction with opposite functions. Accumulating evidences have uncovered the relevance of genetic alterations in these two family members to hematologic malignancies. This review underlines progress in understanding the pathogenesis of these genetic alterations including mutations...

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Identifiers

PMID: 25686120
DOI: 10.2217/fon.14.280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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