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Article

PTP-PEST phosphatase variations in human cancer.

Cancer genetics and cytogenetics - 1 Oct 2006

Streit Sylvia, Ruhe Jens Ernst, Knyazev Pjotr, Knyazeva Tatjana, Iacobelli Stefano, Peter Stephan, Hoefler Heinz, Ullrich Axel

Abstract excerpt

Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. PTP-PEST, a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, and may be involved in metastasis. A search for sequence variations...

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Identifiers

PMID: 16965954
DOI: 10.1016/j.cancergencyto.2006.05.013

Genes

PTPN12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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