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Article

Heterologous T cell immunity in severe hepatitis C virus infection

7 Mar 2005

Abstract excerpt

Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology. To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific...

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PMID: 15753202
DOI: 10.1084/jem.20041058

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