Article
High-throughput screening of extended RAS mutations based on high-resolution melting analysis for prediction of anti-EGFR treatment efficacy in colorectal carcinoma.
Clinical biochemistry - 1 Dec 2014
Ishige Takayuki, Itoga Sakae, Sato Kenichi, Kitamura Kouichi, Nishimura Motoi, Sawai Setsu, Matsushita Kazuyuki, Suzuki Kazufumi, Ota Satoshi, Miyauchi Hideaki, Matsubara Hisahiro, Nakatani Yukio, Nomura Fumio
Abstract excerpt
OBJECTIVES: Recent studies have demonstrated that, in advanced colorectal carcinoma (CRC) patients, extended RAS (in KRAS exons 2-4 and NRAS exons 2-4) and BRAF mutations are negative predictors for anti-EGFR treatment efficacy and negative prognostic factor, respectively. Thus, high-throughput and cost-effective methods for identification of the mutation status are required. DESIGN AND METHODS: We developed a...
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